Proposed Rule Would Drastically Restrict Chimp Research

New rules for labs that use chimpanzees as test subjects may be on the horizon. From the New York Times blog: "The Fish and Wildlife Service proposal came in response to a petition filed in 2010 by the Jane Goodall Institute, the Humane Society of the United States, the Association of Zoos and Aquariums and other groups. It would require permits for interstate commerce involving any chimpanzees, or for what the law calls 'taking,' which could be anything from harassment to major harm to something as simple as obtaining a blood sample. And those permits, Mr. Ashe said, would be granted only if the action could be shown to benefit the survival of the species. If the new rule is enacted, it will be a major success for animal welfare groups, a grave disappointment for some scientists and another sign of the profound changes over the last half-century in the way animals are used and imagined in science and popular culture." The L.A. Times lauds the proposed rule change in an editorial.

Source: http://rss.slashdot.org/~r/Slashdot/slashdotScience/~3/zY80s_TNekg/story01.htm

great pacific garbage patch ben affleck and jennifer garner google privacy changes windows 8 preview leap year moratorium dwts season 14 cast

Researchers demonstrate use of stem cells to analyze causes, treatment of diabetes

June 17, 2013 ? A team from the New York Stem Cell Foundation (NYSCF) Research Institute and the Naomi Berrie Diabetes Center of Columbia University has generated patient-specific beta cells, or insulin-producing cells, that accurately reflect the features of maturity-onset diabetes of the young (MODY).

The researchers used skin cells of MODY patients to produce induced pluripotent stem (iPS) cells, from which they then made beta cells. Transplanted into a mouse, the stem cell-derived beta cells secreted insulin in a manner similar to that of the beta cells of MODY patients. Repair of the gene mutation restored insulin secretion to levels seen in cells obtained from healthy subjects. The findings were reported today in the Journal of Clinical Investigation.

Previous studies have demonstrated the ability of human embryonic stem cells and iPS cells to become beta cells that secrete insulin in response to glucose or other molecules. But the question remained as to whether stem cell-derived beta cells could accurately model genetic forms of diabetes and be used to develop and test potential therapies.

"We focused on MODY, a form of diabetes that affects approximately one in 10,000 people. While patients and other models have yielded important clinical insights into this disease, we were particularly interested in its molecular aspects -- how specific genes can affect responses to glucose by the beta cell," said co-senior author Dieter Egli, PhD, Senior Research Fellow at NYSCF, who was named a NYSCF-Robertson Stem Cell Investigator in 2012.

MODY is a genetically inherited form of diabetes. The most common form of MODY, type 2, results in a loss-of-function mutation in one copy of the gene that codes for the sugar-processing enzyme glucokinase (GCK). With type 2 MODY, higher glucose levels are required for GCK to metabolize glucose, leading to chronic, mildly elevated blood sugar levels and increased risk of vascular complications.

MODY patients are frequently misdiagnosed with type 1 or 2 diabetes. Proper diagnosis can not only change the patient's course of treatment but affect family members, who were previously unaware that they, too, might have this genetic disorder.

NYSCF scientists took skin cells from two Berrie Center type 2 MODY patients and "reprogrammed" -- or reverted -- them to an embryonic-like state to become iPS cells. To examine the effect of the GCK genetic mutation, they also created two genetically manipulated iPS cell lines for comparison: one fully functional (two correct copies of the GCK gene) and one with complete loss of function (two faulty copies of the GCK gene). They then generated beta cell precursors from the fully functional and loss-of-function iPS cell lines and transplanted the cells for further maturation into immune-compromised mice.

"Our ability to create insulin-producing cells from skin cells, and then to manipulate the GCK gene in these cells using recently developed molecular methods, made it possible to definitively test several critical aspects of the utility of stem cells for the study of human disease," said Haiqing Hua, PhD, lead author on the paper, a postdoctoral fellow in the Division of Molecular Genetics, Department of Pediatrics and Naomi Berrie Diabetes Center at Columbia University and the New York Stem Cell Foundation Research Institute.

When given a glucose tolerance test three months later, mice with MODY beta cells had decreased sensitivity to glucose but a normal response to other molecules that stimulate insulin secretion. This is the hallmark of MODY. Mice with two faulty copies of the GCK gene secreted no additional insulin in response to glucose. When the researchers repaired the GCK mutation using molecular techniques, cells with two restored copies of GCK responded normally to the glucose stress test. Unlike other reported techniques, the researchers' approach efficiently repaired the GCK mutation without introducing any potentially harmful additional DNA.

"Generation of patient-derived beta cells with gene correction could ultimately prove to be a useful cell-replacement therapy by restoring patients' ability to regulate their own glucose. This result is truly exciting," said Susan L. Solomon, Chief Executive Officer of The New York Stem Cell Foundation.

The researchers also used an electron microscope to assess beta cells for insulin content by counting granules -- packages that store insulin for release. Even though all beta cell types had a similar number of granules, complete loss of function of the GCK gene was associated with decreased beta-cell production.

"These studies provide a critical proof-of-principle that genetic characteristics of patient-specific insulin-producing cells can be recapitulated through use of stem cell techniques and advanced molecular biological manipulations. This opens up strategies for the development of new approaches to the understanding, treatment, and, ultimately, prevention of more common types of diabetes," said co-senior author Rudolph Leibel, MD, Christopher Murphy Memorial Professor of Diabetes Research, Columbia University Medical Center, and Director, Division of Molecular Genetics, and Co-Director of the Naomi Berrie Diabetes Center.

The other authors are: Linshan Shang and Hector Martinez of the New York Stem Cell Foundation Research Institute; and Matthew Freeby, Mary Pat Gallagher, Thomas Ludwig, Liyong Deng, Ellen Greenberg, Charles LeDuc, Wendy K. Chung, and Robin Goland of the Division of Molecular Genetics, Department of Pediatrics, and Naomi Berrie Diabetes Center at Columbia University.

Funding for this study was provided by: The New York Stem Cell Foundation; the Russell Berrie Foundation; the Leona M. and Harry B. Helmsley Charitable Trust; the Hunter Eastman Scholar Award in Translational Diabetes Research; the James and Irene Hunter Charitable Fund; an ADA-Mentored Fellowship to H. Hua; and NIH Grants RO1 DK52431 and P30DK063608.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/FXGpi6up-oM/130617173129.htm

Candice Glover Warriors Dick Trickle the office Granbury Texas CA Lottery madonna

Putin: US-Russia positions on Syria don't coincide

ENNISKILLEN, Northern Ireland (AP) ? Russian President Vladimir Putin (POO'-tihn) has told President Barack Obama that their positions on Syria do not coincide but both leaders agree on the need to push for negotiations in Syria's two-year-old civil war.

Obama concedes that they have a "different perspective" on Syria but they have a shared interest in stopping the violence and securing chemical weapons in the country.

Obama met with Putin at the G-8 summit in Northern Ireland to discuss the fierce fighting in Syria.

While Putin has called for negotiated peace talks, he has not called for Syrian President Bashar Assad (bah-SHAR' AH'-sahd) to leave power, and he remains one of Assad's strongest political and military allies.

Source: http://news.yahoo.com/putin-us-russia-positions-syria-dont-coincide-195423583.html

printable bracket game change own stacy francis tournament brackets 2012 ncaa basketball tournament walt

Accidentally fell

• Reputation:
  Words written:
  Words per post:
  Joined:
  Last visit:
  Location:
  Website:
  

A girl name Misao Souen runs to hide in a well shrine only to trip and fall in she save sesshomaru's ward and they fall in love

Owner:

Game Masters:

This topic is an Out Of Character part of the roleplay, ?Accidentally fell?. Anything posted here will also show up there.

Topic Tags:

Forum for completely Out of Character (OOC) discussion, based around whatever is happening In Character (IC). Discuss plans, storylines, and events; Recruit for your roleplaying game, or find a GM for your playergroup.

First post: ? 1 post ? Page 1 of 1

This is the auto-generated OOC topic for the roleplay "Accidentally fell"

You may edit this first post as you see fit.

MisaoSouen

Member for 0 years

---

---

First post: ? 1 post ? Page 1 of 1

Post a reply

RolePlayGateway is a site built by a couple roleplayers who wanted to give a little something back to the roleplay community. The site has no intention of earning any profit, and is paid for out of their own pockets.

If you appreciate what they do, feel free to donate your spare change to help feed them on the weekends. After selecting the amount you want to donate from the menu, you can continue by clicking on PayPal logo.

Our Sponsors

RolePlayGateway is proudly powered by obscene amounts of caffeine, duct tape, and support from people like you. It operates under a "don't like it, suggest an improvement" platform, and we gladly take suggestions for improvements or changes.

The custom-built "roleplay" system was designed and implemented by Eric Martindale as of July 2009. All attempts to replicate or otherwise emulate this system and its method of organizing roleplay are strictly prohibited without his express written and contractual permission; violators will be prosecuted to the fullest extent of the law.

? RolePlayGateway, LLC | with the support of LocalSense

Source: http://feedproxy.google.com/~r/RolePlayGateway/~3/1P56Ge90xyE/viewtopic.php

sheriff joe arpaio limbaugh aaron smith wilt chamberlain joe arpaio cat in the hat green eggs and ham

Redskins' RG3 says he'll be ready for July camp

Washington Redskins quarterback Robert Griffin III throws a pass during team practice at Redskins Park, Thursday, June 6, 2013, in Ashburn, Va. (AP Photo/Luis M. Alvarez)

Washington Redskins quarterback Robert Griffin III throws a pass during team practice at Redskins Park, Thursday, June 6, 2013, in Ashburn, Va. (AP Photo/Luis M. Alvarez)

Washington Redskins quarterback Robert Griffin III talks to the media after NFL football team practice at Redskins Park, Thursday, June 6, 2013, in Ashburn, Va. (AP Photo/Luis M. Alvarez)

Washington Redskins quarterback Robert Griffin III drops back for a pass during team practice at Redskins Park, Thursday, June 6, 2013, in Ashburn, Va. (AP Photo/Luis M. Alvarez)

Washington Redskins quarterback Robert Griffin III, left, stretches his leg with the assistance of a Redskins staff member during team practice at Redskins Park, Thursday, June 6, 2013, in Ashburn, Va. (AP Photo/Luis M. Alvarez)

ASHBURN, Va. (AP) ? Quarterback Robert Griffin III says "without a doubt" that he expects to be fully recovered from knee surgery and in uniform when the Washington Redskins open training camp on July 25 in Richmond.

Griffin said Thursday he's confident because "it's a mindset" and because of how his surgically repaired right knee has progressed. The QB says "training camp's a month and a half away. That's why I say without a doubt."

He had knee surgery on Jan. 9 to repair the ACL and LCL he had torn during the playoff loss to Seattle three days earlier.

Coach Mike Shanahan says Griffin was initially projected to miss seven-to-nine months. That would mean Griffin wouldn't return before Aug. 9, the day after Washington opens its preseason schedule against Tennessee.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2013-06-06-FBN-Redskins-Griffin/id-cab00b1d7465462f9acd6bb198ac5ce5

elite eight stephon marbury the lion king suzanne collins cherry blossom festival nc state erika van pelt

Does oral sex cause throat cancer?

This summary is not available. Please click here to view the post.

NASA Teams With LEGO To Offer Model Competition

I mean, why NASA has to go the LEGO route when free and opensource 3D raytracing programs are available to all ?

Furthermore, constructing space crafts using LEGO means people are unnecessarily being restricted by availability of the shape/size/color of the LEGO blocks

On 3D programs people get to create whatever shape/size and use whatever color they want, on their creations

Source: http://rss.slashdot.org/~r/Slashdot/slashdotScience/~3/P5X37iazbNo/story01.htm

earthquake california douglas adams brandon knight brandon knight daylight savings time The Bachelor 2013 Time